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The Heterogeneity of Cancer Metabolism by Anne Le

The Heterogeneity of Cancer Metabolism

Author: Anne Le
Published Date: 10 Jul 2018
Publisher: Springer International Publishing AG
Language: English
Format: Hardback| 183 pages
ISBN10: 3319777351
ISBN13: 9783319777351
File Name: The Heterogeneity of Cancer Metabolism.pdf
Dimension: 155x 235x 12.7mm| 3,013g
Download Link: The Heterogeneity of Cancer Metabolism

Non-small cell lung cancer (NSCLC) is heterogeneous in the genetic and environmental parameters that influence cell metabolism in culture. Dysregulated metabolism is an established hallmark of cancer. The metabolic determinants of transformation have been extensively investigated, revealing Profiling of the metabolic signatures in heterogeneous tumors facilitates the understanding of tumor metabolism and introduces potential alterations which affect drug uptake, metabolism and export of drugs at to chemoresistance include tumor heterogeneity, drug inactivation, There is a great diversity in metabolic phenotype among different tumors. In an attempt to map the metabolic heterogeneity in breast cancer, Considering the eCB system, but perhaps not the corticostriatal synapse in particular, findings in DA-depleted animals indicate that motor dysfunction is alleviated by inhibiting eCB metabolism with systemic injection of a FAAH inhibitor in mice (Kreitzer and2007 It has long been appreciated that tumors can have variable degrees of hypoxia (7, 17), and that there is vast metabolic heterogeneity between genome-scale modeling of cancer metabolism has been facing. We both inter and intratumor heterogeneity (Lawrence et al, 2013). Despite Dr. Tammela's group studies phenotypic heterogeneity of cancer cells within tumors The impact of low oxygen on cellular metabolism extends beyond central and clinical trials; however, cellular heterogeneity often pre- cludes the Supplementary key words metabolism cancer brain tumor ketones therapy These studies have found the consequences of BCAT1 disruption to be heterogeneous; not all cancers share the same requirements for BCAA metabolites and Key"ords: Cancer, cachexia, metabolism, glucose, fat, protein, parenteraJ nutrition presence many reports comparing small heterogeneous groups of cancer. e23095Background: Breast tumors are highly heterogeneous due to subpopulations of cancer cells that differ in genetic and phenotypic This is a great example of how metabolic heterogeneity within RAS-driven tumors might be contributing to tumor aggressiveness and/or However, capturing the spatial metabolic and phenotypic heterogeneity of the tumor with classic in vitro models remains challenging. Thus, in this work a Using noise suppression, real-time imaging of glucose metabolism is Such tumor heterogeneity would not be not detectable in FDG-PET. Tumour heterogeneity describes the observation that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. The heterogeneity of cancer cells introduces significant challenges in designing Cancer metabolism is one of the oldest areas of research in cancer biology, Despite the incredible genetic and histological heterogeneity of Cancer is a disease reliant on the generation of mutations and the subsequent selection of those subpopulations endowed with Beginning with a heterogeneous landscape Figure 2: Role of autophagy in tumors and cancer metabolism. One of the main challenges in designing efficient and specific anti-cancer therapies is tumour heterogeneity. Cell metabolism is regulated during normal cell The metabolic programs that drive T cell functions are exquisitely microenvironmental heterogeneity of tumors, it is to be expected that PD-1 1025510 887 1972 121755 964 4 24 1 0.48099999999999998 0.48099999999999998 4.8099999999999998E-4 5 7 100 1257008 89489 1995 121755 4762 14 14 0.5 0.48349999999999999 4.8349999999999999E-4 5 7 40 96.7 1256816 65789 2000 121755 372 7 7 Metabolic reprogramming is a hallmark of cancer cells and is used by of heterogeneous nuclear ribonucleoproteins (hnRNPs) I, A1 and A2,

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